abstract：:Several studies have proposed a relationship between blood pressure and inflammation. Interleukin-6 (IL-6) is a multifunctional cytokine involved in inflammation and tissue injury and potentially influencing blood pressure. Recently, a common polymorphism of the IL-6 gene, associated with differences in the transcript...

journal_title：Journal of human hypertension

authors： Pola R,Flex A,Gaetani E,Pola P,Bernabei R

更新日期：2002-09-01 00:00:00

abstract：:The aim of the study was to investigate the effect of therapy by rilmenidine on endothelial and platelet function in 23 patients with the early stages of untreated essential hypertension. The measurements were carried out before therapy, after 1 week of placebo administration, after 1 week, after 1 month and after 3 m...

journal_title：Journal of human hypertension

authors： Remková A,Kratochvíl'ová H

更新日期：2002-08-01 00:00:00

abstract：:Large-scale trials with angiotensin converting enzyme (ACE) inhibitors and angiotensin II type 1 (AT(1))-receptor blockers have clearly shown that blockade of the renin-angiotensin system reduces the deterioration in renal function associated with diabetes. AT(1)-receptor blockers represent a more rational approach to...

journal_title：Journal of human hypertension

authors： Hollenberg NK

更新日期：2002-08-01 00:00:00

abstract：:This article reviews the current literature regarding the role of home measurement of blood pressure (BP) in the management of hypertension. Subjects with hypertension can use simple automated devices to measure their own BP at home. The results can be accurate and reliable, and because multiple readings allow a mean ...

journal_title：Journal of human hypertension

authors： Rickerby J

更新日期：2002-07-01 00:00:00

abstract：:Hypertension and knee osteoarthritis (OA) are frequent comorbidities. Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to relieve pain in such patients. In the last decade selective NSAIDs are used more commonly since they lead to less gastrointestinal complications. As has been shown, the treatment with N...

journal_title：Journal of human hypertension

authors： Reitblat T,Zamir D,Estis L,Priluk R,Drogenikov T,Viskoper JR

更新日期：2002-06-01 00:00:00

abstract：:The purpose of this study was to estimate the current prevalence and distribution of hypertension in an adult Tehranian population. Data were collected for 3343 men and 5148 women aged 20-69 years in the Tehran Lipid and Glucose Study (TLGS), which is a cross-sectional phase of a large epidemiologic study, first estab...

journal_title：Journal of human hypertension

authors： Azizi F,Ghanbarian A,Madjid M,Rahmani M

更新日期：2002-05-01 00:00:00

abstract：:We describe three patients with abdominal aortic aneurysm (AAA) and renal artery stenosis (RAS). These patients were treated by placement of an aortic endograft and angioplasty or stenting of the renal artery. After the procedure renal function improved or remained stable in two patients and deteriorated slightly in o...

journal_title：Journal of human hypertension

authors： Agroyannis B,Chatziioannou A,Mourikis D,Patsakis N,Katsenis K,Kalliafas S,Dimakakos P,Vlachos L

更新日期：2002-05-01 00:00:00

abstract：:The objective of this study was to examine the effect of angiotensin II (Ang II) and angiotensin II type 1 (AT(1)) receptor blockade on pulse wave velocity (PWV) in healthy humans. We studied nine young male volunteers in a double-blind randomised crossover design. Carotid-femoral PWV (an index of arterial stiffness) ...

journal_title：Journal of human hypertension

authors： Rehman A,Rahman AR,Rasool AH

更新日期：2002-04-01 00:00:00

abstract：:In this study we investigated the role of endogenous endothelin in the cardiovascular response to acute stress, ie mild footshocks in conscious rats. Footshock-stress significantly increased mean arterial pressure and heart rate (P < 0.05). Peripheral or intracerebroventricular (IVT) administration of BQ 788, a select...

journal_title：Journal of human hypertension

authors： Garrido MR,Israel A

更新日期：2002-03-01 00:00:00

abstract：:Microalbuminuria (urinary albumin excretion equal to 30-300 mg/24 h) is a reliable indicator of premature cardiovascular mortality in diabetic patients and in the general population. In insulin-dependent and non-insulin-dependent diabetes mellitus microalbuminuria is a marker of initial diabetic nephropathy and predic...

journal_title：Journal of human hypertension

authors： Crippa G

更新日期：2002-03-01 00:00:00

abstract：:Non-modulating is a highly reproducible type of sodium-sensitive hypertension. The aim of this study was to evaluate in non-modulating individuals the erythrocyte sodium-lithium countertransport (SLC) abnormalities, which have been mentioned as a marker of non-modulation, and the association with increased microalbumi...

journal_title：Journal of human hypertension

authors： Sánchez RA,Giannone C,Masnatta LD,Baglivo HP,Ramírez AJ

更新日期：2002-03-01 00:00:00

abstract：:Haemorrhagic diathesis develops in chronic renal failure, in which calcium antagonists are used widely as antihypertensive agents. Although calcium antagonists are reported to impair platelet function, it has not been examined whether calcium antagonists alter bleeding time. The present study was conducted to clarify ...

journal_title：Journal of human hypertension

authors： Hayashi K,Matsuda H,Honda M,Ozawa Y,Tokuyama H,Okubo K,Takamatsu I,Kanda T,Tatematsu S,Homma K,Saruta T

更新日期：2002-03-01 00:00:00

abstract：:Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis origi...

journal_title：Journal of human hypertension

authors： Nawrot TS,Thijs L,Den Hond EM,Roels HA,Staessen JA

更新日期：2002-02-01 00:00:00

abstract：:Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, a...

journal_title：Journal of human hypertension

authors： Lind H,Edvinsson L

更新日期：2002-01-01 00:00:00

abstract：:The aim of this preliminary study was to determine whether young offspring of first cousin hypertensive parent(s), have higher blood pressure (BP) reactivity in response to their first BP measurement, as compared to the offspring of first cousin normotensive parents. The BP of 135 boys aged 9-10 years was measured, fo...

journal_title：Journal of human hypertension

authors： Hassan MO,Al Kharusi W,Ziada A

更新日期：2001-12-01 00:00:00

abstract：:This report analysed data from the Health Survey for England 1994 to evaluate blood pressure (BP) management in relation to cigarette smoking. Data were analysed for 12 013 adults aged > or = 16 years living in England in 1994. Among 2280 subjects with BP > or = 160/95 mm Hg or treated with BP-lowering medication, rat...

journal_title：Journal of human hypertension

authors： Gulliford MC

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To assess the association between different antihypertensive drug regimens and plasma lipid levels in the general population. METHODS:The Monitoring Project on Cardiovascular Risk Factors was conducted from 1987 to 1991 as a cross-sectional study in The Netherlands. Antihypertensive drug-users and untreated ...

journal_title：Journal of human hypertension

authors： Maitland-van der Zee AH,Klungel OH,Kloosterman JM,Seidell JC,Leufkens HG,de Boer A

更新日期：2001-10-01 00:00:00

abstract：:We sought to assess the haemodynamic effects of clonidine on left ventricular (LV) pressure-volume relation in patients with diastolic heart dysfunction due to essential hypertension. Towards this end, simultaneous recordings of LV volume (acoustic quantification) and LV pressure (micromanometer) were obtained in 10 s...

journal_title：Journal of human hypertension

authors： Stefanadis C,Manolis A,Dernellis J,Tsioufis C,Tsiamis E,Gavras I,Gavras H,Toutouzas P

更新日期：2001-09-01 00:00:00

abstract：:Hypertension is poorly managed. Hospital-based pharmacists working with physicians have been shown to improve the rate of achievement of "target" blood pressure in selected patients. It is unknown if such schemes can operate in the community and to what extent they would attract volunteers with poorly managed blood pr...

journal_title：Journal of human hypertension

authors： Earle KA,Taylor P,Wyatt S,Burnett S,Ray J

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy, tolerability, and safety of once-daily therapy with amlodipine 5 mg/benazepril 10 mg vs amlodipine 5 mg, benazepril 10 mg, and placebo. DESIGN:Randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. SETTING:Twenty-two clinical centres, including private prac...

journal_title：Journal of human hypertension

authors： Pool J,Kaihlanen P,Lewis G,Ginsberg D,Oparil S,Glazer R,Messerli FH

更新日期：2001-07-01 00:00:00

abstract：:This study endeavours to clarify the effect of alcohol consumption on changes in the blood pressure of Japanese men. The subjects, who were followed from 1990 to 1995, were 2189 male normotensive steelworkers aged from 40 to 54 years in 1990. Drinking habits were represented by two variables: average daily baseline al...

journal_title：Journal of human hypertension

authors： Okubo Y,Suwazono Y,Kobayashi E,Nogawa K

更新日期：2001-06-01 00:00:00

abstract：:The last decade has seen the publication of different editions of guidelines for the pharmacological treatment of hypertension that were based on the results of large, randomised trials. Since these guidelines were meant to inform practitioners, we analysed the pattern of prescription of antihypertensive agents betwee...

journal_title：Journal of human hypertension

authors： Onder G,Gambassi G,Landi F,Pedone C,Cesari M,Carbonin PU,Bernabei R,Investigators of the GIFA Study (SIGG-ONLUS).

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Hypertension is associated with increased urinary calcium excretion (UCa). A high sodium intake increases both UCa and blood pressure (BP). However, it is not clear whether these effects are modified by gender or ethnic origin. OBJECTIVES:To examine the relationships between BP, urinary sodium (UNa), gender...

journal_title：Journal of human hypertension

authors： Blackwood AM,Sagnella GA,Cook DG,Cappuccio FP

更新日期：2001-04-01 00:00:00

abstract：:Submaximal exercise systolic blood pressure (ExSBP) is a recognised predictor of cardiac mortality. This study examined the possibility that this might be related to increased QT dispersion or prolonged maximum QT(c) interval (QTcmax). Twenty-nine untreated hypertensive subjects were assessed. Each subject underwent a...

journal_title：Journal of human hypertension

authors： Lim PO,Rana BS,Struthers AD,MacDonald TM

更新日期：2001-03-01 00:00:00

abstract：:The aim of this study was to investigate the influence of ambient temperature on blood pressure (BP). BP measurements were taken in 20 normotensive volunteers who stayed in Greenland for a 6-week period. Measurements of systolic (SBP), diastolic (DBP) and heart rate (HR) were taken before (3 sessions), during (7-8 ses...

journal_title：Journal of human hypertension

authors： Jansen PM,Leineweber MJ,Thien T

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Disturbance in calcium metabolism has been suggested in the pathogenesis of hypertension, however, membrane calcium content in humans has not been studied in detail yet in primary hypertension. We compared plasma, intracellular and membrane calcium concentrations in erythrocytes of patients with essential hy...

journal_title：Journal of human hypertension

authors： Kosch M,Hausberg M,Barenbrock M,Posadzy-Malaczynska A,Rahn KH,Kisters K

更新日期：2001-01-01 00:00:00

abstract：:Prevalence, awareness, treatment and control of hypertension were assessed in 1032 (90%) of 1147 elderly (> or = 65 years) inhabitants of three Italian villages. Blood pressure (BP) was measured at home on two separate occasions following a standardised protocol. Persons taking antihypertensive drugs or with BP values...

journal_title：Journal of human hypertension

authors： Prencipe M,Casini AR,Santini M,Ferretti C,Scaldaferri N,Culasso F

更新日期：2000-12-01 00:00:00

abstract：:The prevention and treatment of hypertension both from the viewpoint of individual patient care and in terms of population health presents a considerable challenge to the medical profession. To assist in meeting this challenge, various bodies have produced guidelines for the management of hypertension during the past ...

journal_title：Journal of human hypertension

authors： Mancia G,Grassi G

更新日期：2000-10-01 00:00:00

abstract：:Hypertension in women has received less attention than hypertension in men, and the major controlled trials of antihypertensive therapy have been carried out in populations made up predominantly of and have emphasised outcomes in men. Recently it has been recognised that women develop high blood pressure, particularly...

journal_title：Journal of human hypertension

authors： Rosenthal T,Oparil S

更新日期：2000-10-01 00:00:00

abstract：:Platelet shape change (PSC) is an early phase of platelet activation that precedes platelet aggregation. This phase of platelet activation is essentially aspirin resistant. PSC was monitored, by measuring the median platelet volume (MPV) using a high resolution channelyser. Angiotensin (Ang) II, added in vitro, caused...

journal_title：Journal of human hypertension

authors： Jagroop IA,Mikhailidis DP

更新日期：2000-09-01 00:00:00

abstract：:The present study was conducted to determine whether Valyl-Tyrosine (VY) has an antihypertensive effect on high-normal blood pressure and mild essential hypertension, as well as spontaneous hypertensive rats (SHR). A randomised double-blind placebo-controlled study was carried out on 29 volunteers. A 100-ml drink cont...

journal_title：Journal of human hypertension

authors： Kawasaki T,Seki E,Osajima K,Yoshida M,Asada K,Matsui T,Osajima Y

更新日期：2000-08-01 00:00:00

abstract：:This meta-analysis attempted to derive pooled estimates for the putative association between echocardiographic or electrocardiographic left ventricular hypertrophy and the deletion/insertion (D/I) polymorphism of the angiotensin-I converting enzyme. Case-control studies were combined, using the Mantel and Haenszel app...

journal_title：Journal of human hypertension

authors： Kuznetsova T,Staessen JA,Wang JG,Gasowski J,Nikitin Y,Ryabikov A,Fagard R

更新日期：2000-07-01 00:00:00

abstract：:Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of mark...

journal_title：Journal of human hypertension

authors： Knight J,Gardner GT,Clark AJ,Caulfield MJ

更新日期：2000-06-01 00:00:00

abstract：:The insertion/deletion polymorphism (I/D) of the angiotensin-converting enzyme (ACE) gene has been associated in some studies with a higher prevalence of left ventricular hypertrophy (LVH), but few of them were performed on pharmacologically treated hypertensive patients. The present study was undertaken to determine ...

journal_title：Journal of human hypertension

authors： López-Contreras J,Blanco-Vaca F,Borrás X,Carreras F,Pons-Lladó G,Gallego F,Solé MJ,Cirera S,Benet MT,Negredo E,Roca-Cusachs A

更新日期：2000-05-01 00:00:00

abstract：AIMS:To define the prevalence of hypertension, a major cause of morbidity and mortality in blacks, and related biosocial factors in an urban African population group. METHODS:The setting was that of a civil service population in Ibadan, a major city in Southwestern Nigeria. Nine hundred and ninety-eight civil servants...

journal_title：Journal of human hypertension

authors： Olatunbosun ST,Kaufman JS,Cooper RS,Bella AF

更新日期：2000-04-01 00:00:00

abstract：:Footshocks increases mean arterial pressure and heart rate. Systemic or intracerebroventricular (IVT) administration of losartan, a specific angiotensin AT1 receptor antagonist, not only inhibited the pressor response to footshocks but resulted in vasodepression. Peripheral or IVT administration of PD 123319, a specif...

journal_title：Journal of human hypertension

authors： Sosa-Canache B,Cierco M,Gutierrez CI,Israel A

更新日期：2000-04-01 00:00:00

abstract：:Hypertension prevalence rates remain comparatively low in Nigeria, although the associated morbidity and mortality including that due to malignant hypertension (MHT) is considerable. To determine the factors that may be associated with the development of MHT we compared 74 patients with essential MHT (age 48 +/- 9 yea...

journal_title：Journal of human hypertension

authors： Kadiri S,Olutade BO,Osobamiro O

更新日期：2000-03-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) levels and ACE gene polymorphisms have been related with hypertension but with contradictory results between populations. We have investigated the association among the allelic distribution of the insertion-deletion (I/D) polymorphism of the ACE gene, identified by polymerase chain ...

journal_title：Journal of human hypertension

authors： Martínez E,Puras A,Escribano J,Sanchis C,Carrión L,Artigao M,Divisón JA,Massó J,Vidal A,Fernández JA

更新日期：2000-02-01 00:00:00

abstract：:Previous studies have suggested that the Trp460 allele of the Gly460Trp polymorphism in the alpha-adducin gene is associated with salt sensitivity and primary hypertension. The present study was undertaken to evaluate if the Trp460 allele of this polymorphism is associated with primary hypertension in Scandinavians. T...

journal_title：Journal of human hypertension

authors： Melander O,Bengtsson K,Orho-Melander M,Lindblad U,Forsblom C,Råstam L,Groop L,Hulthén UL

更新日期：2000-01-01 00:00:00

abstract：:Within routine clinical practice, white coat hypertension (where blood pressure is persistently higher in the presence of the doctor or nurse but normal outside the medical setting) makes the diagnosis and management of hypertension difficult. There are conflicting data regarding the prevalence and significance of whi...

journal_title：Journal of human hypertension

authors： Manning G,Rushton L,Millar-Craig MW

更新日期：1999-12-01 00:00:00